This paper questions the anthropocentrism of Peter Sloterdijk’s "spherology", with its anthropogenesis as the immunological making of the “house of Being” in which humans break from animal “cage” and build spheres, immunological islands of human coexistence. Orpheus’s myth represents immunology to Sloterdijk: in losing his loved one, Orpheus immunologically rebuilds the supplement, neutralizing the absent ghost as language. One proposes a philosophical experiment, the “Anti-Orpheus”, in which Viveiros de Castro and Tania Stolze Lima’s Cosmological perspectivism, topologically reframed, serves as counterpoint in order to put spherology into perspective, pointing to a variation of inside and outside and to “anthropophagy” as another topologic...